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Article

Alpha-defensin DEFA1A3 gene copy number elevation in Danish Crohn's disease patients.

Digestive diseases and sciences - 1 Dec 2011

Jespersgaard Cathrine, Fode Peder, Dybdahl Marianne, Vind Ida, Nielsen Ole Haagen, Csillag Claudio, Munkholm Pia, Vainer Ben, Riis Lene, Elkjaer Margarita, Pedersen Natalia, Knudsen Elisabeth, Andersen Paal Skytt

Abstract excerpt

BACKGROUND AND PURPOSE OF STUDY: Extensive copy number variation is observed for the DEFA1A3 gene encoding alpha-defensins 1-3. The objective of this study was to determine the involvement of alpha-defensins in colonic tissue from Crohn's disease (CD) patients and the possible genetic association of DEFA1A3 with CD. METHODS: Two-hundred and forty ethnic Danish CD patients were included in the study. Reverse...

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Identifiers

PMID: 21701837
DOI: 10.1007/s10620-011-1794-8

Genes

DEFA1
DEFA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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