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Article

Copy number polymorphism and expression level variation of the human α-defensin genes DEFA1 and DEFA3

8 Jun 2005

Abstract excerpt

We have defined unexpectedly extensive copy number variation at the human anti-microbial alpha-defensin genes DEFA1 and DEFA3, encoding human neutrophil peptides HNP-1, HNP-2 and HNP-3. There was variation in both number and position of DEFA1/DEFA3 genes in arrays of 19 kb tandem repeats on 8p23.1, so that the DEFA1 and DEFA3 genes appear to be interchangeable variant cassettes within tandem gene arrays. For this...

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Advanced biosensing and bioanalysis techniques
Antimicrobial Peptides and Activities
Virology and Viral Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15944200
DOI: 10.1093/hmg/ddi209

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Copy number polymorphism and expression level variation of the human α-defensin genes DEFA1 and DEFA3PMID 15944200Read ↗

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