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Article

Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients.

Mediators of inflammation - 1 Jan 2018

Zhao Jialian, Gu Qiang, Wang Lifeng, Xu Weize, Chu Lihua, Wang Ya, Li Zhongwang, Wu Shuijing, Xu Jianguo, Hu Zhiyong, Shu Qiang, Fang Xiangming

Abstract excerpt

DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1-3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections. To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAIs and 109 controls in the intensive care unit (ICU) and examined their DEFA1/DEFA3 CNVs....

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Source

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Identifiers

PMID: 29950924
DOI: 10.1155/2018/2152650
PMCID: PMC5987315

Genes

DEFA1
DEFA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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