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Article

Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity.

Lupus - 1 Sept 2010

MacDonald C M, Boursier L, D'Cruz D P, Dunn-Walters D K, Spencer J

Abstract excerpt

Affinity maturation is a process by which low-affinity antibodies are transformed into highly specific antibodies in germinal centres. This process occurs by hypermutation of immunoglobulin heavy chain variable (IgH V) region genes followed by selection for high-affinity variants. It has been proposed that statistical tests can identify affinity maturation and antigen selection by analysing the frequency of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20501523
DOI: 10.1177/0961203310367657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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