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Article

Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity.

Lupus - 1 Sept 2010

MacDonald C M, Boursier L, D'Cruz D P, Dunn-Walters D K, Spencer J

Abstract excerpt

Affinity maturation is a process by which low-affinity antibodies are transformed into highly specific antibodies in germinal centres. This process occurs by hypermutation of immunoglobulin heavy chain variable (IgH V) region genes followed by selection for high-affinity variants. It has been proposed that statistical tests can identify affinity maturation and antigen selection by analysing the frequency of...

Topics

Antibody Affinity
Autoimmunity
Binding Sites
Binomial Distribution
Complementarity Determining Regions
Data Interpretation, Statistical
Granulomatosis with Polyangiitis
Humans
Immunoglobulin Heavy Chains
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Reproducibility of Results

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Identifiers

PMID: 20501523
DOI: 10.1177/0961203310367657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20501523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity.PMID 20501523Read ↗

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