Article
Antigen selection in IgE antibodies from individuals with chronic rhinosinusitis with nasal polyps.
American journal of rhinology & allergy - 1 Jan 2000
Pratt Eleanor, Collins Andrew M, Sewell William A, Harvey Richard J
Abstract excerpt
BACKGROUND: It is generally assumed that all immunoglobulin isotopes develop under antigen selection pressure, leading to dramatic increases in antigen-binding affinity. As activated B cells proliferate, somatic mutations accumulate in the regions of the immunoglobulin gene associated with antigen binding. Emerging evidence from studies investigating mutations in variable region sequences of IgE antibodies...
Topics
- Chronic Disease
- Immunoglobulin E
- Immunoglobulin Variable Region
- Mutation
- Nasal Polyps
- Reverse Transcriptase Polymerase Chain Reaction
- Rhinitis
- Sinusitis