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Article

Antigen selection in IgE antibodies from individuals with chronic rhinosinusitis with nasal polyps.

American journal of rhinology & allergy - 1 Jan 2000

Pratt Eleanor, Collins Andrew M, Sewell William A, Harvey Richard J

Abstract excerpt

BACKGROUND: It is generally assumed that all immunoglobulin isotopes develop under antigen selection pressure, leading to dramatic increases in antigen-binding affinity. As activated B cells proliferate, somatic mutations accumulate in the regions of the immunoglobulin gene associated with antigen binding. Emerging evidence from studies investigating mutations in variable region sequences of IgE antibodies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21144221
DOI: 10.2500/ajra.2010.24.3538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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