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Article

Inconclusive evidence for or against positive antigen selection in the shaping of human immunoglobulin E repertoires: a call for new approaches.

International archives of allergy and immunology - 1 Jan 2013

Levin Mattias, Ohlin Mats

Abstract excerpt

BACKGROUND: The mechanisms driving the development of immunoglobulin E (IgE) antibody repertoires are a matter of debate. Alternatives to the classical view on antibody development, involving somatic mutation and antigen-driven selection of high-affinity variants in germinal centers, have been proposed. METHODS: We have re-analyzed the pattern of mutations in previously isolated and characterized human clonally...

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Source

Identifiers

PMID: 23343692
DOI: 10.1159/000345421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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