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Article

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.

AIDS (London, England) - 14 Jan 2018

Beima-Sofie Kristin, Wamalwa Dalton, Maleche-Obimbo Elizabeth, Lingappa Jairam R, Mackelprang Romel, Gantt Soren, John-Stewart Grace, Casper Corey, Slyker Jennifer A

Abstract excerpt

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV...

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Identifiers

PMID: 29112074
DOI: 10.1097/QAD.0000000000001680
PMCID: PMC5736409

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