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Article

Identification of the amino acid residues responsible for stable nucleosome formation by histone H3.Y.

Nucleus (Austin, Tex.) - 4 May 2017

Kujirai Tomoya, Horikoshi Naoki, Xie Yan, Taguchi Hiroyuki, Kurumizaka Hitoshi

Abstract excerpt

Histone H3.Y is conserved among primates. We previously reported that exogenously produced H3.Y accumulates around transcription start sites, suggesting that it may play a role in transcription regulation. The H3.Y nucleosome forms a relaxed chromatin conformation with flexible DNA ends. The H3.Y-specific Lys42 residue is partly responsible for enhancing the flexibility of the nucleosomal DNA. To our surprise, we...

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Identifiers

PMID: 28118111
DOI: 10.1080/19491034.2016.1277303
PMCID: PMC5499910

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Source receipt: pubmed, retrieved 7 Sept 2026.

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