Article

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

2025-09-26

Abstract excerpt

<h4>Summary</h4> Histone variants define distinct chromatin states by modulating the biophysical properties of nucleosomes. Variants play a particularly important role in the parasitic protist Trypanosoma brucei , which has unusual chromatin and lacks a canonical repressive heterochromatin system. Instead, T. brucei utilises specialised divergent histone variants H3.V and H4.V. However, the biochemical basis of...

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Literature Corpus work: 68a01578-5151-51e4-b6d7-9acfa51e2e5f
DOI: 10.1101/2025.09.24.678203

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