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Article

Maintenance of functional equivalence during paralogous Hox gene evolution.

Nature - 10 Feb 2000

Greer J M, Puetz J, Thomas K R, Capecchi M R

Abstract excerpt

Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene complex, a group of 39 genes which are located on 4 linkage groups, dispersed on 4 chromosomes. The evolution of this...

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PMID: 10688203
DOI: 10.1038/35001077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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