Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.

Genes, brain, and behavior - 1 Sept 2022

Regan Samantha L, Sugimoto Chiho, Dawson Hannah E, Williams Michael T, Vorhees Charles V

Abstract excerpt

Latrophilin-3 (LPHN3) is a brain specific G-protein coupled receptor associated with increased risk of attention deficit hyperactivity disorder (ADHD) and cognitive deficits. CRISPR/Cas9 was used to generate a constitutive knockout (KO) rat of Lphn3 by deleting exon 3, based on human data that LPHN3 variants are associated with some cases of ADHD. Lphn3 KO rats are hyperactive with an attenuated response to ADHD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Locomotion
Share to Maze Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Rats, Sprague-Dawley

Share to Receptors, G-Protein-Coupled

Share to Receptors, Peptide

Share to Reflex, Startle

Source

Open in PubMed Open full text

Identifiers

PMID: 35985692
DOI: 10.1111/gbb.12817
PMCID: PMC9744505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.PMID 35985692Read ↗

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.Semantic proximity Read ↗

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.Semantic proximity Read ↗

Behavioral Testing Design for Evaluation of Cognitive Disabilities.Semantic proximity Read ↗

Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.Semantic proximity Read ↗

Circuits activated by psychiatric-associated behavior: from brain-wide labeling to regional assessment using Psych-TRAP.Semantic proximity Read ↗

Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD.Semantic proximity Read ↗

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.Semantic proximity Read ↗

Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice.Semantic proximity Read ↗

Behavioral phenotyping of an improved mouse model of Phelan-McDermid Syndrome with a complete deletion of the <i>Shank3</i> geneSemantic proximity Read ↗

Attractin Gene Deficiency in Rats Leads to Impairments in Both Activity and Spatial Learning and Memory.Semantic proximity Read ↗

Behavioral Phenotyping of an Improved Mouse Model of Phelan-McDermid Syndrome with a Complete Deletion of the Shank3 Gene.Semantic proximity Read ↗

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.