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Article

Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway.

Experimental lung research - 1 Jun 2010

Woo Hyun-Jae, Yoo Woo Jong, Bae Chang Hoon, Song Si-Youn, Kim Yong-Woon, Park So-Young, Kim Yong-Dae

Abstract excerpt

Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signaling pathways. The expression of the leptin receptor was evaluated in human nasal mucosa and...

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Source

Identifiers

PMID: 20497020
DOI: 10.3109/01902140903427033

Genes

STAT3
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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