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Article

Discovering statistically significant pathways in expression profiling studies

8 Sept 2005

Abstract excerpt

Accurate and rapid identification of perturbed pathways through the analysis of genome-wide expression profiles facilitates the generation of biological hypotheses. We propose a statistical framework for determining whether a specified group of genes for a pathway has a coordinated association with a phenotype of interest. Several issues on proper hypothesis-testing procedures are clarified. In particular, it is...

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PMID: 16174746
DOI: 10.1073/pnas.0506577102

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