Article
Identification of functional modules that correlate with phenotypic difference: the influence of network topology.
Genome biology - 1 Jan 2010
Hung Jui-Hung, Whitfield Troy W, Yang Tun-Hsiang, Hu Zhenjun, Weng Zhiping, DeLisi Charles
Abstract excerpt
One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method...
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