Article
Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2017
Vilaseca Marina, García-Calderó Héctor, Lafoz Erica, Ruart Maria, López-Sanjurjo Cristina Isabel, Murphy Michael P, Deulofeu Ramon, Bosch Jaume, Hernández-Gea Virginia, Gracia-Sancho Jordi, García-Pagán Juan Carlos
Abstract excerpt
BACKGROUND & AIMS: In cirrhosis, activated hepatic stellate cells (HSC) play a major role in increasing intrahepatic vascular resistance and developing portal hypertension. We have shown that cirrhotic livers have increased reactive oxygen species (ROS), and that antioxidant therapy decreases portal pressure. Considering that mitochondria produce many of these ROS, our aim was to assess the effects of the oral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.