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Article

Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats.

International journal of molecular sciences - 31 Oct 2023

Hafez Hala A, Atoom Ali M, Khafaga Rana H M, Shaker Sara A, Kamel Maher A, Assem Nagwa M, Mahmoud Shimaa A

Abstract excerpt

(1) Background: Hepatitis C virus (HCV) infection is endemic in Egypt, with the highest prevalence rate worldwide. Sofosbuvir (SOF) is a nucleos(t)ide analog that specifically inhibits HCV replication. This study aimed to explore the possible effects of the therapeutic dose of SOF on the mitochondrial biogenesis and functions of the liver, muscle, and ovarian tissues of young normal female rats. (2) Methods: This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37958828
DOI: 10.3390/ijms242115844
PMCID: PMC10647297

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