Article
Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2010
Vallance Kelly, Liu Wei, Mandrell Belinda N, Panetta John C, Gattuso Jami S, Hockenberry Marilyn, Zupanec Sue, Yang Lei, Yang Jie, Hinds Pamela S
Abstract excerpt
BACKGROUND: Dexamethasone contributes to high cure rates in paediatric acute lymphoblastic leukaemia (ALL) but significantly and adversely alters sleep and fatigue. Herein we explored three mechanisms (pharmacokinetics, serum albumin and pharmacogenetics) through which dexamethasone may cause debilitating fatigue and disrupted sleep. METHODS: We enrolled 100 patients on a 10-d study: 5-d of no dexamethasone (OFF...
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