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Article

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.

European journal of clinical pharmacology - 1 Dec 2018

Kim Hannah Yejin, Veal Gareth J, Zhou Fanfan, Boddy Alan V

Abstract excerpt

BACKGROUND: Actinomycin D is used for treatment of paediatric cancers; however, a large inter-patient pharmacokinetic (PK) variability and hepatotoxicity are significant limitations to its use and warrant further investigation. Elimination of actinomycin D may be mediated by transporters, as the drug does not seem to undergo significant metabolism. We investigated the role of solute carrier (SLC) transporters in...

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PMID: 30167756
DOI: 10.1007/s00228-018-2544-z

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