Article
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia.
Blood - 1 Jan 2004
Kishi Shinji, Yang Wenjian, Boureau Benoit, Morand Stanislas, Das Soma, Chen Peixian, Cook Edwin H, Rosner Gary L, Schuetz Erin, Pui Ching-Hon, Relling Mary V
Abstract excerpt
Etoposide is a substrate for P-glycoprotein, CYP3A4, CYP3A5, and UGT1A1. Glucocorticoids modulate CYP3A and P-glycoprotein in preclinical models, but their effect on clinical etoposide disposition is unknown. We studied the pharmacokinetics of etoposide and its catechol metabolite in children with acute lymphoblastic leukemia, along with polymorphisms in CYP3A4, CYP3A5, MDR1, GSTP1, UGT1A1, and VDR. Plasma...
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