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Article

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2011

White-Koning Melanie, Civade Elodie, Geoerger Birgit, Thomas Fabienne, Le Deley Marie-Cécile, Hennebelle Isabelle, Delord Jean-Pierre, Chatelut Etienne, Vassal Gilles

Abstract excerpt

PURPOSE: The aim of this pharmacokinetic-pharmacodynamic (PK-PD) analysis was to evaluate the pharmacologic characteristics of erlotinib and its main metabolite (OSI-420) in pediatric patients compared with those in adult patients. EXPERIMENTAL DESIGN: Plasma concentrations of erlotinib and OSI-420 of 46 children with malignant brain tumors included in a phase I study and 42 adults with head and neck carcinoma...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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PMID: 21653689
DOI: 10.1158/1078-0432.CCR-10-3278

Genes

ABCB1
ABCG2

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