Article

Pharmacogenetic and Clinical Predictors of Ondansetron Failure in a Diverse Pediatric Oncology Population

2021-08-23

Abstract excerpt

<title>Abstract</title> <p>Purpose: Chemotherapy induced nausea and vomiting (CINV) is a frequently seen burdensome adverse event of cancer therapy. The 5-HT3 receptor antagonist ondansetron has improved the rates of CINV but, unfortunately, up to 30% of patients do not obtain satisfactory control. This study examined whether genetic variations in a relevant drug metabolizing enzyme (CYP2D6), transporter (ABCB1)...

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Literature Corpus work: d62f77a9-7883-5712-ac56-be97c5a9ef7d
DOI: 10.21203/rs.3.rs-762220/v1

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