Article
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis.
Genes and immunity - 1 Jul 2010
Jamieson S E, Peixoto-Rangel A L, Hargrave A C, Roubaix L-A de, Mui E J, Boulter N R, Miller E N, Fuller S J, Wiley J S, Castellucci L, Boyer K, Peixe R G, Kirisits M J, Elias L de Souza, Coyne J J, Correa-Oliveira R, Sautter M, Smith N C, Lees M P, Swisher C N, Heydemann P, Noble A G, Patel D, Bardo D, Burrowes D, McLone D, Roizen N, Withers S, Bahia-Oliveira L M G, McLeod R, Blackwell J M
Abstract excerpt
Congenital Toxoplasma gondii infection can result in intracranial calcification, hydrocephalus and retinochoroiditis. Acquired infection is commonly associated with ocular disease. Pathology is characterized by strong proinflammatory responses. Ligation of ATP by purinergic receptor P2X(7), encoded by P2RX7, stimulates proinflammatory cytokines and can lead directly to killing of intracellular pathogens. To...
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