Article
Evaluation of the poly(ADP-ribose) polymerase gene in human stroke.
Atherosclerosis - 1 Feb 2000
Kato N, Morita H, Sugiyama T, Kurihara H, Tsubaki S, Nabika T, Kitamura K, Yamori Y, Yazaki Y
Abstract excerpt
Nitric oxide (NO) and its reactant product, peroxynitrite, have been implied to mediate neuronal damage following cerebral ischemia. However, the cellular targets of these compounds remain unclear. Studies using poly(ADP-ribose) polymerase (PARP) inhibitors and PARP knock-out mice have recently d...
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