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Article

The Genetic Regulation of ADPRT/PARP-1 in Aging and Cancer Susceptibility.

2005-03-01

Abstract excerpt

The ADP-ribosyltransferase (ADPRT) gene encodes the poly(ADP-ribose)polymerase-1 (PARP-1) enzyme, which plays critical roles in DNA-damage signaling and repair, cell death, maintenance of genomic stability, and carcinogenesis. It may also serve as a potential target for cancer therapy. In this review, we evaluate findings from animal model systems and molecular epidemiological studies to demonstrate the potential...

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Literature Corpus work
1ade377b-d21b-5088-b863-b20c2703afcd
DOI
10.2174/1570160053175054
Open publication

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