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Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease

9 Apr 2022

Abstract excerpt

Alzheimer’s disease (AD) is an irreversible age-related neurodegenerative disorder clinically characterized by severe memory impairment, language deficits and cognitive decline. The major neuropathological hallmarks of AD include extracellular deposits of the β-amyloid (Aβ) peptides and cytoplasmic neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein. The accumulation of plaques and tangles in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35455964
DOI: 10.3390/cells11081284

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