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Article

Generation of an OMgp allelic series in mice.

Genesis (New York, N.Y. : 2000) - 1 Nov 2009

Lee Jae K, Case Lauren C, Chan Andrea F, Zhu Yuhong, Tessier-Lavigne Marc, Zheng Binhai

Abstract excerpt

The very limited ability to regenerate axons after injury in the mature mammalian central nervous system (CNS) has been partly attributed to the growth restrictive nature of CNS myelin. Oligodendrocyte myelin glycoprotein (OMgp) was identified as a major myelin-derived inhibitor of axon growth. However, its role in axon regeneration in vivo is poorly understood. Here we describe the generation and molecular...

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Identifiers

PMID: 19672953
DOI: 10.1002/dvg.20557
PMCID: PMC2788017

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Source receipt: pubmed, retrieved 7 Sept 2026.

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