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Article

Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2016

Kuzmanov Uros, Guo Hongbo, Buchsbaum Diana, Cosme Jake, Abbasi Cynthia, Isserlin Ruth, Sharma Parveen, Gramolini Anthony O, Emili Andrew

Abstract excerpt

Phospholamban (PLN) plays a central role in Ca2+ homeostasis in cardiac myocytes through regulation of the sarco(endo)plasmic reticulum Ca2+-ATPase 2A (SERCA2A) Ca2+ pump. An inherited mutation converting arginine residue 9 in PLN to cysteine (R9C) results in dilated cardiomyopathy (DCM) in humans and transgenic mice, but the downstream signaling defects leading to decompensation and heart failure are poorly...

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Share to Calcium-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27742792
DOI: 10.1073/pnas.1606444113
PMCID: PMC5098613

Genes

PLN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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