Article
Zinc supplement greatly improves the condition of parkin mutant Drosophila.
Biological chemistry - 1 May 2010
Saini Nidhi, Schaffner Walter
Abstract excerpt
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many...
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