Article

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in <i>Pink1/parkin</i> models

2023-05-14

Abstract excerpt

<h4>Background</h4> Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional analysis of genes linked to PD have revealed that the E3 ligase Parkin and the mitochondrial kinase PINK1 are important factors for mitochondrial quality control. PINK1 phosphorylates and activates Parkin, whic...

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Literature Corpus work: 8775b407-39e4-5b6f-9604-1d9cfb8ceaa2
DOI: 10.1101/2023.05.14.540700

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