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Article

Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.

Biochemical and biophysical research communications - 20 Oct 2020

Xue Jinsong, Wang Hui-Li, Xiao Guiran

Abstract excerpt

Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in Parkinson's disease (PD). In recent years, environmental toxins are employed to increase oxidative stress mediated neuropathology and sporadic PD. Disruption of iron homeostasis has been implicated in PD patients for many years, but the functional role of iron in sporadic PD pathogenesis is still not well clarified...

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PMID: 32800558
DOI: 10.1016/j.bbrc.2020.07.025

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