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Article

The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.

Marine drugs - 21 Apr 2010

Cervenka René, Zarrabi Touran, Lukacs Peter, Todt Hannes

Abstract excerpt

The outer vestibule of voltage-gated Na(+) channels is formed by extracellular loops connecting the S5 and S6 segments of all four domains ("P-loops"), which fold back into the membrane. Classically, this structure has been implicated in the control of ion permeation and in toxin blockage. However, conformational changes of the outer vestibule may also result in alterations in gating, as suggested by several...

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Identifiers

PMID: 20479982
DOI: 10.3390/md8041373
PMCID: PMC2866490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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