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Article

Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture.

The Journal of general virology - 1 Jun 2010

Dargan Derrick J, Douglas Elaine, Cunningham Charles, Jamieson Fiona, Stanton Richard J, Baluchova Katarina, McSharry Brian P, Tomasec Peter, Emery Vincent C, Percivalle Elena, Sarasini Antonella, Gerna Giuseppe, Wilkinson Gavin W G, Davison Andrew J

Abstract excerpt

Mutations that occurred during adaptation of human cytomegalovirus to cell culture were monitored by isolating four strains from clinical samples, passaging them in various cell types and sequencing ten complete virus genomes from the final passages. Mutational dynamics were assessed by targeted sequencing of intermediate passages and the original clinical samples. Gene RL13 and the UL128 locus (UL128L,...

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Identifiers

PMID: 20479471
DOI: 10.1099/vir.0.018994-0
PMCID: PMC3052722

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Source receipt: pubmed, retrieved 7 Sept 2026.

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