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Article

Information processing at the foxa node of the sea urchin endomesoderm specification network.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010

de-Leon Smadar Ben-Tabou, Davidson Eric H

Abstract excerpt

The foxa regulatory gene is of central importance for endoderm specification across Bilateria, and this gene lies at an essential node of the well-characterized sea urchin endomesoderm gene regulatory network (GRN). Here we experimentally dissect the cis-regulatory system that controls the complex pattern of foxa expression in these embryos. Four separate cis-regulatory modules (CRMs) cooperate to control foxa...

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Identifiers

PMID: 20479235
DOI: 10.1073/pnas.1004824107
PMCID: PMC2890477

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GRN

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