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Article

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo.

Development (Cambridge, England) - 20 Jan 2021

Floc'hlay Swann, Molina Maria Dolores, Hernandez Céline, Haillot Emmanuel, Thomas-Chollier Morgane, Lepage Thierry, Thieffry Denis

Abstract excerpt

During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral organiser region specifies the ventral and dorsal territories. This process relies on a complex interplay between the Nodal and BMP pathways through numerous regulatory circuits. To decipher the interplay between these pathways, we used a combination of treatments with recombinant Nodal and...

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PMID: 33298464
DOI: 10.1242/dev.189944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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