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Article

The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

Molecular cell - 14 May 2010

Chin Y Rebecca, Toker Alex

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently deregulated in cancer. Downstream of PI3K, Akt1 and Akt2 have opposing roles in breast cancer invasive migration, leading to metastatic dissemination. Here, we identify palladin, an actin-associated protein, as an Akt1-specific substrate that modulates breast cancer cell invasive migration. Akt1, but not Akt2, phosphorylates palladin at...

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Identifiers

PMID: 20471940
DOI: 10.1016/j.molcel.2010.02.031
PMCID: PMC2872630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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