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PI3K signaling-mediated BAP1 O-GlcNAcylation promotes breast cancer malignancy by dual regulation of OGT stability and FOXM1 condensation

2026-06-10

Abstract excerpt

<title>Abstract</title> <p> Phosphoinositide 3-kinase (PI3K) pathway plays a central role in tumor development and progression, and is frequently activated in human breast cancers. However, the mechanism underlying PI3K-mediated regulation of breast cancer growth and metastasis remains poorly understood. Here we show that the activation of PI3K contributes to breast cancer progression by regulating the downstrea...

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Literature Corpus work
ed2c1345-9994-5656-83b4-752a82d5b9e0
DOI
10.21203/rs.3.rs-9896114/v1
Open publication

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PI3K signaling-mediated BAP1 O-GlcNAcylation promotes breast cancer malignancy by dual regulation of OGT stability and FOXM1 condensationDOI 10.21203/rs.3.rs-9896114/v1
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