Article
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
Neoplasia (New York, N.Y.) - 1 Aug 2012
Gagliardi Paolo Armando, di Blasio Laura, Orso Francesca, Seano Giorgio, Sessa Roberto, Taverna Daniela, Bussolino Federico, Primo Luca
Abstract excerpt
3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling pathway because it phosphorylates Akt/PKB through interactions with phosphatidylinositol 3,4,5 phosphate. Recent data indicate that PDK1 is overexpressed in many breast carcinomas and that alterations of PDK1 are critical in the context of oncogenic PI3K activation. However, the role...
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