PAK-dependent regulation of actin dynamics in breast cancer cells

doi:10.1016/j.biocel.2022.106207

Article

PAK-dependent regulation of actin dynamics in breast cancer cells

3 Apr 2022

Abstract excerpt

Metastatic Breast Cancer has a poor 25% survival rate and currently there are no clinical therapeutics which target metastasis. 'Migrastatics' are a new drug class which target migration pathway effector proteins in order to inhibit cancer cell invasion and metastasis. The p21-activated kinases (PAKs) are essential drivers of breast cancer cell migration and invasion through their regulation of actin cytoskeletal...

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