Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

Molecular cell - 20 Nov 2014

Gasser Jessica A, Inuzuka Hiroyuki, Lau Alan W, Wei Wenyi, Beroukhim Rameen, Toker Alex

Abstract excerpt

Oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI3K), occur with high frequency in breast cancer. The protein kinase Akt is considered to be the primary effector of PIK3CA, although mechanisms by which PI3K mediates Akt-independent tumorigenic signals remain obscure. We show that serum and glucocorticoid-regulated kinase 3 (SGK3) is amplified in breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Mice, Nude
Share to Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Transplantation

Share to NIH 3T3 Cells

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25458846
DOI: 10.1016/j.molcel.2014.09.023
PMCID: PMC4255362

Genes

SGK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.PMID 25458846Read ↗

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Semantic proximity Read ↗

SGK1 in Human Cancer: Emerging Roles and MechanismsSemantic proximity Read ↗

INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomasSemantic proximity Read ↗

Elevated PI3K signaling drives multiple Breast Cancer subtypesSemantic proximity Read ↗

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.Semantic proximity Read ↗

The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human CancerSemantic proximity Read ↗

High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancerSemantic proximity Read ↗

Phosphoinositide-3-Kinase Enhancers, PIKEs: Their Biological Functions and Roles in Cancer.Semantic proximity Read ↗

p110δ PI3 kinase pathway: emerging roles in cancerSemantic proximity Read ↗

Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cellsSemantic proximity Read ↗

PI3K Signaling in Glioma—Animal Models and Therapeutic ChallengesSemantic proximity Read ↗

Signalling specificity in the Akt pathway in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.