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Article

MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.

Oncogene - 5 Aug 2010

Chen J, Miller E M, Gallo K A

Abstract excerpt

The malignant phenotype in breast cancer is driven by aberrant signal transduction pathways. Mixed-lineage kinase-3 (MLK3) is a mammalian mitogen-activated protein kinase kinase kinase (MAP3K) that activates multiple MAPK pathways. Depending on the cellular context, MLK3 has been implicated in apoptosis, proliferation, migration and differentiation. Here we investigated the effect of MLK3 and its signaling to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20514022
DOI: 10.1038/onc.2010.198

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