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Article

Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases.

Experimental cell research - 15 Aug 2010

Lin Lin, McCroskery Seumas, Ross Jaime M, Chak Yvonne, Neuhuber Birgit, Daniels Mathew P

Abstract excerpt

Filopodia sense the extracellular environment and direct movement in many cell types, including neurons. Recent reports suggest that the transmembrane form of the widely expressed proteoglycan agrin (TM-agrin) regulates formation and stability of neuronal filopodia. In order to elucidate the mechanism by which TM-agrin regulates filopodia, we investigated the role of agrin's glycosaminoglycan (GAG) chains in the...

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Identifiers

PMID: 20471381
DOI: 10.1016/j.yexcr.2010.05.006
PMCID: PMC2902627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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