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Article

The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

1 May 2021

Abstract excerpt

During heart development, epicardial cells residing within the outer layer undergo epithelial-mesenchymal transition (EMT) and migrate into the underlying myocardium to support organ growth and morphogenesis. Disruption of epicardial EMT results in embryonic lethality, yet its regulation is poorly understood. Here, we report epicardial EMT within the mesothelial layer of the mouse embryonic heart at ultra-high...

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PMID: 33969874
DOI: 10.1242/dev.197525

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