Article
Screening of novel dominant negative mutant actins using glycine targeted scanning identifies G146V actin that cooperatively inhibits cofilin binding.
Biochemical and biophysical research communications - 11 Jun 2010
Noguchi Taro Q P, Toya Ryo, Ueno Hironori, Tokuraku Kiyotaka, Uyeda Taro Q P
Abstract excerpt
A number of studies suggested that the structure of actin filaments changes by interaction with actin-binding proteins such as cofilin and myosin, and that the conformational changes of the actin subunits within a filament are cooperative. To understand the functions of these cooperative conformational changes induced by actin-binding proteins, we sought to obtain dominant negative mutant actins impaired in...
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