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Article

G146V mutation at the hinge region of actin reveals a myosin class-specific requirement of actin conformations for motility.

The Journal of biological chemistry - 13 Jul 2012

Noguchi Taro Q P, Komori Tomotaka, Umeki Nobuhisa, Demizu Noriyuki, Ito Kohji, Iwane Atsuko Hikikoshi, Tokuraku Kiyotaka, Yanagida Toshio, Uyeda Taro Q P

Abstract excerpt

The G146V mutation in actin is dominant lethal in yeast. G146V actin filaments bind cofilin only minimally, presumably because cofilin binding requires the large and small actin domains to twist with respect to one another around the hinge region containing Gly-146, and the mutation inhibits that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22637580
DOI: 10.1074/jbc.M111.321752
PMCID: PMC3397860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22637580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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