Article
Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.
PLoS genetics - 1 Dec 2011
Chan Yingleong, Holmen Oddgeir L, Dauber Andrew, Vatten Lars, Havulinna Aki S, Skorpen Frank, Kvaløy Kirsti, Silander Kaisa, Nguyen Thutrang T, Willer Cristen, Boehnke Michael, Perola Markus, Palotie Aarno, Salomaa Veikko, Hveem Kristian, Frayling Timothy M, Hirschhorn Joel N, Weedon Michael N
Abstract excerpt
Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain, as is the extent to which common variation is relevant to individuals with more extreme phenotypes. To address...
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