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Article

Genome-wide association analysis identifies 20 loci that influence adult height.

Nature genetics - 1 May 2008

Weedon Michael N, Lango Hana, Lindgren Cecilia M, Wallace Chris, Evans David M, Mangino Massimo, Freathy Rachel M, Perry John R B, Stevens Suzanne, Hall Alistair S, Samani Nilesh J, Shields Beverly, Prokopenko Inga, Farrall Martin, Dominiczak Anna, Johnson Toby, Bergmann Sven, Beckmann Jacques S, Vollenweider Peter, Waterworth Dawn M, Mooser Vincent, Palmer Colin N A, Morris Andrew D, Ouwehand Willem H, Zhao Jing Hua, Li Shengxu, Loos Ruth J F, Barroso Inês, Deloukas Panagiotis, Sandhu Manjinder S, Wheeler Eleanor, Soranzo Nicole, Inouye Michael, Wareham Nicholas J, Caulfield Mark, Munroe Patricia B, Hattersley Andrew T, McCarthy Mark I, Frayling Timothy M

Abstract excerpt

Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify genetic variants influencing adult human height, we used genome-wide association data from 13,665 individuals and genotyped 39 variants in an additional 16,482 samples. We identified 20 variants associated with adult height (P < 5 x 10(-7), with 10 reaching P < 1 x...

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Identifiers

PMID: 18391952
DOI: 10.1038/ng.121
PMCID: PMC2681221

Genes

ACAN
ADAMTSL3
CDK6
DLEU7
EFEMP1
HHIP
HMGA2
IHH
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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