Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2015

Yang Tie-Lin, Guo Yan, Zhang Ji-Gang, Xu Chao, Tian Qing, Deng Hong-Wen

Abstract excerpt

Runs of homozygosity (ROHs), in which both parental alleles are identical, have been proposed to have recessive effects on multiple human complex diseases. Osteoporosis is a common complex disease characterized by low bone mineral density (BMD), which is highly heritable. And recessive loci that contribute to BMD variations have been identified. In this study, we performed a genome-wide ROHs association study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Density
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Hip Fractures

Share to Homozygote

Share to Molecular Sequence Annotation

Share to Osteoporotic Fractures

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 25983029
DOI: 10.1002/jbmr.2558
PMCID: PMC4615523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations.PMID 25983029Read ↗

Runs of homozygosity identify a recessive locus 12q21.31 for human adult height.Semantic proximity Read ↗

The distribution and functional relevance analysis of runs of homozygosity (ROHs) in Chinese Han female population.Semantic proximity Read ↗

Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population.Semantic proximity Read ↗

Regions of homozygosity and their impact on complex diseases and traits.Semantic proximity Read ↗

A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human major histocompatibility complex.Semantic proximity Read ↗

Large-Scale Genome-Wide Linkage Analysis for Loci Linked to BMD at Different Skeletal Sites in Extreme Selected SibshipsSemantic proximity Read ↗

Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer.Semantic proximity Read ↗

Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population.Semantic proximity Read ↗

Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study.Semantic proximity Read ↗

Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese.Semantic proximity Read ↗

Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.Semantic proximity Read ↗

A recessive genetic model and runs of homozygosity in major depressive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.