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Article

Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations.

Human molecular genetics - 1 Aug 2010

Barekati Zeinab, Radpour Ramin, Kohler Corina, Zhang Bei, Toniolo Paolo, Lenner Per, Lv Qing, Zheng Hong, Zhong Xiao Yan

Abstract excerpt

The present study investigated promoter hypermethylation of TP53 regulatory pathways providing a potential link between epigenetic changes and mitochondrial DNA (mtDNA) alterations in breast cancer patients lacking a TP53 mutation. The possibility of using the cancer-specific alterations in serum...

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Source

Identifiers

PMID: 20466735
DOI: 10.1093/hmg/ddq199

Genes

PTEN
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20466735-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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