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Article

G:C > A:T mutations and potential epigenetic regulation of p53 in breast cancer.

Breast cancer research and treatment - 1 Dec 2007

Kouidou Sofia, Malousi Andigoni, Kyventidis Anastasios, Fragou Aikaterini, Maglaveras Nicos

Abstract excerpt

Analysis of germline p53 mutations in breast cancer reveals that the Li-Fraumeni and Li-Fraumeni-like syndromes are mostly related to the loss of initiation codon 133 of regulatory TP53 isoforms (Delta133p53). In eight codons of exons 5-8 (including 133), mutations are frequent in Li-Fraumeni-related, but scarce in sporadic breast cancer, while in six more codons they are frequent both in familial and sporadic...

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Source

Identifiers

PMID: 17505880
DOI: 10.1007/s10549-007-9514-y

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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