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Article

Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and TP53 Mutation Status in Triple-Negative Cases.

International journal of molecular sciences - 6 Dec 2022

Sadzeviciene Ieva, Snipaitiene Kristina, Scesnaite-Jerdiakova Asta, Daniunaite Kristina, Sabaliauskaite Rasa, Laurinaviciene Aida, Drobniene Monika, Ostapenko Valerijus, Jarmalaite Sonata

Abstract excerpt

This study aimed at analyzing the DNA methylation pattern and TP53 mutation status of intrinsic breast cancer (BC) subtypes for improved characterization and survival prediction. DNA methylation of 17 genes was tested by methylation-specific PCR in 116 non-familial BRCA mutation-negative BC and 29 control noncancerous cases. At least one gene methylation was detected in all BC specimens and a 10-gene panel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36499753
DOI: 10.3390/ijms232315429
PMCID: PMC9741387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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